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Evidence for the treatment of acute joint pain with topical diclofenac gels


An ex-vivo study on human skin samples showed that topical diclofenac not only penetrates the skin but also forms a reservoir of the drug in the epidermis. Confirmation that the drug reaches the site ...

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Autor: Daniela DeutschEFSM: 2021;1:210313 DOI: 10.52778/efsm.21.0313Data: 22.09.2021

Meta-analysis on the role of exercise in the treatment of constipation


Current guidelines recommend life-style adjustment (including more exercise) as the first measure for treating constipation. This meta-analysis investigated the influence of exercise therapy on the sy ...

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Autor: Thomas Weiser, PhD și Sabine Landes, PhDEFSM: 2021;1:210001DOI: 10.52778/efsm.21.0001Data: 16.08.2021

Acute cough: for the first time, a clear recommendation for ambroxol as symptomatic treatment


According to the guidelines of the German Respiratory Society, an acute cold cough without clinical indications of pneumonia or other warning signs, is the domain of self-medication. The duration – up ...

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Autor: Tobias Mück, PhDEFSM: 2021;1:210002DOI: 10.52778/efsm.21.0002Data: 16.08.2021

Ambroxol reduces cough frequency (in the daytime and at night) and thereby improves concentration …


The pharmacy-based study questioned customers who had used one of four different dosage forms of ambroxol for acute cough. The results illustrated the therapeutic benefits of ambroxol in self-medicati ...

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Autor: Tobias Mück, PhDEFSM: 2021;1:210003DOI: 10.52778/efsm.21.0003Data: 16.08.2021

Relief of acute cough by cough syrup with mucoprotection


Two randomised, blind, controlled, multicentre studies investigated the therapeutic effect of a chemical and mechanical barrier in the upper airways produced by polysaccharide-resin-honey based cough ...

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Autor: Tobias Mück, PhDEFSM: 2021;1:210004DOI: 10.52778/efsm.21.0004Data: 16.08.2021

Marshmallow root extract and honey: cough relief through mucoprotection


The experimental study investigated the bioadhesive properties of cough syrups containing partial fractions of plant extracts with or without added honey. The study authors established that addition o ...

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Autor: Tobias Mück, PhDEFSM: 2021;1:210005DOI: 10.52778/efsm.21.0005Data: 16.08.2021

Female-specific characteristics in the occurrence and treatment of constipation


Constipation not only has an impact on daily bowel movements, but also on the well-being of the persons concerned. An online survey of more than 5,000 people showed that women are often more extensive ...

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Autor: Sabine Landes, PhDEFSM: 2021;1:210006DOI: 10.52778/efsm.21.0006Data: 16.08.2021

Pharmacokinetics of ibuprofen: comparison of the fixed combination of ibuprofen plus caffeine with …

Results of two single-dose studies (randomised, single centre, crossover, open-label)


Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastroin ...

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Autor: Thomas Weiser, PhDEFSM: 2021;1:210007DOI: 10.52778/efsm.21.0007Data: 16.08.2021

Efficacy, safety and tolerability of the fixed combination of ibuprofen (400 mg) and caffeine (100 …

Results of a clinical study (randomised, placebo-controlled, double-blind)


Does combining ibuprofen with caffeine have advantages over ibuprofen alone in the treatment of acute pain? A randomised, placebo-controlled, double-blind study compared efficacy, safety and tolerabil ...

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Autor: Thomas Weiser, PhDEFSM: 2021;1:210008DOI: 10.52778/efsm.0008Data: 16.08.2021

Abdominal pain, cramping and discomfort impair women's quality of life: an internet-based …


In this internet-based observational study, 96% of the women questioned reported that abdominal pain, cramping and discomfort sometimes interfered with their everyday activities; 44% even stated that ...

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Autor: Harald Weigmann, PhDEFSM: 2021;1:210009DOI: 10.52778/efsm.21.0009Data: 16.08.2021