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Tab. 1. Pharmacokinetic properties of ibuprofen enantiomers (according to Evans et al. 2001 [3])…Efficacy and tolerability Conclusions Literature Summary Dexibuprofen: licensed as COX inhibitor in 23 countries Pharmacokinetics…Conflict of interest: The authors A. Gažová and J. Kyselovič declare no conflict of interest. E. Koscova is an employee of Sanofi.   General properties…Dexibuprofen – a portrait

Literature …Cough especially common in children Clinical evidence in small children Clinical studies with 1300 children [2]…Colds and bronchitis are very frequently associated with acute cough. In children, an acute cough lasts an average of 25 days and is sometimes very burdensome…Efficacy and tolerability of ambroxol in children

Letteratura…Metodi Discussione e conclusioni Risultati…Weiser et al. Efficacy and safety of a fixed-dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third…La farmacocinetica dell'ibuprofene: confronto tra la combinazione a dose fissa ibuprofene più caffeina, ibuprofene sale di lisina e ibuprofene acido

Letteratura…I disturbi associati a stitichezza acuta o cronica sono tra i sintomi più frequentemente menzionati in farmacia da coloro che ricorrono all’automedicazione…Specificità dei soggetti di sesso femminile relativamente all'incidenza e al trattamento della stitichezza

Ichthyol® in self-medication Resistance is not the only problem Pale and dark forms of Ichthyol® have antibacterial activity Literature Antibiotics increase…Patients frequently show abscesses which, in the terminology of dermatologists, “are not yet ripe” i.e., they are not fluctuant and no pus emerges on incision…Update on the antibiotic treatment of uncomplicated skin abscesses

Literature…Fig. 1. Effects of supplementation with a combination of vitamins, minerals and Panax ginseng root dry extract in 103 healthy subjects presenting fatigue…Daily intake of Panax ginseng extract (G115®) supplemented with vitamins and minerals reduces self-perception of mental and physical fatigue

Literature…Circadian rhythms of the gut are orchestrated by an interaction between central and peripheral clocks: the suprachiasmatic nucleus (SCN), acting as the…Circadian rhythm and its potential influence on gut motility

Literature …What can be derived from these treatment guidelines for the relief of occasional abdominal pain?  Analgesics in abdominal pain? Conclusions…All the guidelines recommend the use of antispasmodics (also known as spasmolytics) for the treatment of abdominal pain (see Table). In addition to the…Guideline recommendations for the treatment of abdominal pain (in irritable bowel syndrome)

Letteratura…Risultati Metodi Discussione e conclusioni…Fig. 2: Percentuale di pazienti che hanno sperimentato un sollievo dal dolore significativo entro 0-6 ore dall’assunzione della preparazione in esame Derry…Efficacia, sicurezza e tollerabilità della combinazione a dose fissa ibuprofene (400 mg) più caffeina (100 mg) rispetto a ibuprofene, caffeina e placebo

Letteratura …Rilevanza per la pratica farmaceutica Una recente meta-analisi ne conferma efficacia e sicurezza…Fig. 3: Effetti indesiderati dell’olio di menta piperita rispetto al placebo Forest plot di una meta-analisi di otto studi clinici randomizzati controllati…Recente meta-analisi sull’efficacia dell’olio di menta piperita nella sindrome dell’intestino irritabile